Naslov
Sex Related Differences in Cardiovascular Health and Microvascular Reactivity Among Healthy Student Population

Autori
Stupin, Marko ; Stupin, Ana ; Rašić, Lidija ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Hypertension (September 2016 - Volume 34 - e-Supplement 2 - ESH 2016 Abstract Book) / - , 2016, PP1210-PP1210

Skup
ESH 2016 (26th Meeting on Hypertension and Cardiovascular Protection)

Mjesto i datum
Pariz, Francuska, 10.06.2016. - 13.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cardivascular health ; microvascular reactivity ; sex differences

Sažetak
Objective: It is increasingly recognized that differences in the clinical presentations of cardiovascular diseases in women compared to men may be related to microvascular reactivity (MR). The aim of this study was to assess if there are sex related differences in microvascular reactivity and cardiovascular health in young healthy students of both sexes, as possible prospective determinant of future cardiovascular health. Design and method: 99 young healthy women (age 21 +/- 2 years) and 44 young healthy man students (age 21 +/- 2 years) were included in this study. Body Mass Index (BMI), waist-to-hip ratio (WHR), systolic (SBP), diastolic (DBP) and mean arterial blood pressure (MAP) and heart rate (HR) were measured in all participants. Post-occlusive reactive hyperemia (PORH) in the skin microcirculation after 1', 2' and 3' vascular occlusion period (measure of MR) was assessed by laser Doppler flowmetry (LDF). Results: BMI and WHR were significantly higher in male compared to female students (BMI, kg/m2 men 23.9 +/- 2.8 vs. women 22.1 +/- 3.1, P < 0.001 ; WHR men 0.79 +/- 0.04 vs. women 0.73 +/- 0.04, P < 0.001). SBP, DBP and MAP were significantly higher in otherwise normotensive men compared to women (MAP/mmHg, men 95 +/- 9 vs. women 82 +/- 7, P < 0.001). HR was higher in women compared to men (HR, /min, men 74 +/- 11 vs. women 65 +/- 11, P < 0.001). PORH was significantly higher in women compared to man students in all three measured points. SBP and MR (r = -0.224, P = 0.028) and WHR and MR in women (r = -0.238, P = 0.019) significantly negatively correlated, but no association of DBP, MAP or HR or BMI with MR was observed in the same group. In contrast, in male students there was no association of any measured parameter with MR. Conclusions: Our results show sex-related differences in MR, as well as in blood pressure in examined participants suggesting different physiological mechanisms of MR in women compared to men. Having in mind important differences in clinical presentation of cardiovascular diseases in women compared in men it is necessary to study more thoroughly sex differences in MR, since MR is crucial in etiopathogenesis of these diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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