Naslov
Clusters of male and female Alzheimer's disease patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database

Autori
Gamberger, Dragan ; Zenko, Bernard ; Mitelpunkt, Alexis ; Shachar, Netta ; Lavrac, Nada

Izvornik
Brain informatics (2198-4018) 3 (2016), 3; 169-179

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer’s disease ; Clustering ; Female and male subpopulations

Sažetak
This paper presents homogeneous clusters of patients, identified in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer’s disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo, Temeljne medicinske znanosti

POVEZANOST RADA