Naslov
Impact of chronic bronchial infection on the lungs and beyond

Autori
Matkovic, Zinka ; Tudoric, Neven ; Miravitlles, Marc

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
European Respiratory Monograph

Urednik/ci
Welte, Tobias ; Blasi, Francesco ; Miravitlles, Marc

Izdavač
European Respiratory Society

Grad
Norwich

Godina
2013

Raspon stranica
46-57

ISBN
978-1-84984-034-7

Ključne riječi
chronic obstructive pulmonary disease, colonisation, comorbidities, exacerbation, infection, inflammation

Sažetak
Impaired host defences in chronic bronchial diseases allow the establishment and proliferation of potentially pathogenic microorganisms (PPMs). This is particularly frequent in patients with chronic obstructive pulmonary disease (COPD). Repeated isolation of PPMs in bronchial secretions in stable patients was defined as colonisation ; however, it is well documented that the presence of PPMs in the lower airways is associated with increased exacerbation frequency and severity, faster lung function decline and worse health status. Therefore, the term chronic bronchial infection (CBI) has been proposed to define this clinical situation. The presence of CBI in COPD is characterised by increased chronic inflammation not only in the airways and lung parenchyma, but also at a systemic level. Current evidence indicates that a significant amount of local and systemic inflammatory response in COPD may be attributable to the presence of PPMs. Since atherosclerosis is also characterised by chronic inflammation and oxidative stress, it has been hypothesised that CBI may be responsible for some extrapulmonary manifestations of COPD, particularly the high prevalence of cardiovascular comorbidities.

Izvorni jezik
Engleski

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