Naslov
1, 2, 3-Triazole appended L-ascorbic acid with antioxidant properties

Autori
Meščić, Andrijana ; Harej, Anja ; Kraljević Pavelić, Sandra ; Stepanić, Višnja ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry / - , 2016, 1-1

Skup
17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry

Mjesto i datum
Sitges, Španjolska, 28.06.2016. - 01.07.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
L-askorbinska kiselina ; 1 ; 2 ; 3-triazol ; hvatač radikala ; antitumorski agens
(L-ascorbic acid ; 123-triazole ; radical scavenging ; antitumoral agent)

Sažetak
Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Various pyrimidines and purines containing L-ascorbic acid exhibited significant antiproliferative effects against malignant human tumour cell lines.1 Vitamin C is a biologically significant reducing agent due to its 1-oxo-2- ene-2, 3-diol structural moiety. Furthermore, 1, 2, 3-triazoles have attracted considerable attention in recent years because of their wide range of biological activities against various viruses, malignant cells, microorganisms and their inhibitory activities against several enzymes.2 A series of 1, 4-substituted 1, 2, 3-triazole derivatives of L-ascorbic acid have been synthesized as potential antitumor compounds. The influence of the substituent R2 at the C-4 of the triazole ring on the radical scavenging capacity was also examined. Results of the biological evaluations of novel compounds will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA