Naslov
Synthesis and Antitumor Activity of N-Sulfonyl Derivatives and Sulfonamido Nucleoside Derivatives

Autori
Glavaš-Obrovac, Ljubica ; Karner, Ivan ; Krizmanić, Irena ; Žinić, Mladen ; Žinić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XV International Roundtable International Society of Nucleosides, Nucleotides and Nucleic Acids : Book of Abstracts ; u: Nucleosides, Nucleotides Nucleic Acids 15 (2002) / De Clerq, E ; Herdewijin, P - Leuven : Rega Institute for Medical Research, 2002, P377-P377

Skup
International Roundtable International Society of Nucleosides, Nucleotides and Nucleic Acids (15 ; 2002)

Mjesto i datum
Leuven, Belgija, 10.09.2002. - 14.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
synthesis; antitumor activity; N-sulfonyl derivatives; sulfonamido derivatives; nucleobase; nucleosides

Sažetak
We have designed and synthesized N-sulfonyl derivatives of pyrimidine bases as a new type of sulfonylcycloureas. These type of compounds showed potent growth inhibitory activity against human tumor cell lines in vitro, at concentrations of 10-8− 10-5 M (25-75%), and some of them showed the ability to induce apoptosis in treated tumor cells. These results directed our interest toward N-sulfonyl derivatives of purine bases and sulfonamido derivatives of nucleosides. The synthesis involves the reaction of purine base or amino function of modified purine nucleoside with sulfonyl chlorides in pyridine. The introduction of the sulfonamido group on the C-2 position of the pyrimidine nucleosides was achieved by ring opening of 2, 3’ - and 2, 2’ -anhydronucleosides with appropriate sulfonamide anion as nucleophile. The synthesis and antitumor activity of the target nucleoside derivatives will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita

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