Naslov
Koštani status u bolesnika sa šećernom bolesti
(Bone status in patients with diabetes mellitus)

Autori
Šangulin, Morana ; Cvijanović, Olga ; Crnčević Orlić, Željka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
International Student Congress ISC 2016

Mjesto i datum
Graz, Austrija, 26.05.2016. - 28.05.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Šećerna bolest tip 2; Biljezi koštane pregradnje; Koštana denzitometrijaa
(Diabetes mellitus type 2; Bone remodeling markers; Bone densitometry)

Sažetak
Introduction: Decreased insulin secretion, insulin resistance, hyperglycemia and adipokines have important role in metabolic changes of bone tissue in patients with diabetes mellitus type 2 (DMT2). Another factors that affect bone quality in DMT2 are: lifestyle, physical activity and nutrition (intake of calcium, vitamin D, zinc). Aim: Our aim was to define bone status in our patients by measuring serum concentration of bone turnover markers, vitamin D and bone mineral density (BMD) values. In addition, the aim was to analise the influence of adiponectin and IL-6 on bone metabolism, especially in obese patients with DMT2. Patients and methods: Two groups of patients were included: 1. Patients with newly diagnosed diabetes mellitus ; 2. Patients treated with antidiabetic drugs 10 or more than 10 years. From the study group were excluded patients with DMT2, treated with antidiabetic drugs less than 10 years. Serum osteocalcin, crosslaps, IL-6, adiponectin and 25- hydroxyvitamin D were quantified through the ELISA technique. Correlations were investigated using Pearson correlation test. Results were considered statistically significant if P<0, 05. Results: Negative correlation between BMD of lumbar spine and IL-6 has been found in both groups (R=-0, 30, P=0, 05). Serum crosslaps and BMD of the lumbar spine correlated statistically significant and negative in group with newly diagnosed diabetes (R=-0.45, P<0, 05). Although it is not significant, correlation between adiponectin and BMD is positive and on the border of significance (R=0, 27, P=0, 45). Discussion: Adipokines produced by adipose tissue affect bone status in patients with diabetes mellitus.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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