Naslov
Association of pro-inflammatory cytokines with PTSD severity in patients treated with omega-3 supplementation – a pilot study

Autori
Kalinić Dubravka ; Mimica, Ninoslav ; Jerončić, Ana ; Lalovac, Miloš ; Delaš, Ivančica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 24th European Congress of Psychiatry ; European Psychiatry Vol 33 / - Amsterdam : Elsevier, 2016, S254-S254

Skup
Abstracts of the 24th European Congress of Psychiatry

Mjesto i datum
Beč, Austrija, 19.03.2016. - 23.03.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytokines ; pro-inflammatory ; patients ; posttraumatsic stress disorder ; PTSD ; omega-3 ; supplementation ; study

Sažetak
Introduction Association of pro-inflammatory cytokines with severity of various psychiatric disorders is shown. Evidence suggests omega- 3 fatty acids reduce psychiatric symptoms due to anti-inflammatory properties. Objectives To evaluate if serum levels of pro- inflammatory cytokines correlate with the intensity of PTSD symptoms, and the observed change in symptoms' severity induced by omega-3 supplementation. Methods We included 26 Croatian Homeland war veterans (aged 39- 60) with chronic PTSD and no major comorbidity, who were on stable therapeutic sertraline dose at least three months before recruitment. Levels of pro-inflammatory cytokines (TNF-a, IL-6, and 1L-Ip) were determined by the enzyme- linked immunosorbent assay method. Intensity of PTSD symptomatology was assessed by Clinician- Administered PTSD Scale (CAPS), Hamilton Anxiety Scale (HAM-A) and 17-item Hamilton Depression Scale (17-HAM-D). During 12 weeks, participants i ook omega-3 capsules (600 mg/day) while continuing sertraline therapy. Results Most participants presented with moderate PTSD evaluated by CAPS. At baseline, cytokine levels were not associated with the severity of PTSD symptoms, as measured by all three scales (P> 0.209). After 12 weeks of omega-3 supplementation the severity of PTSD symptoms significantly decreased, on average by 8 to 13% on the psychometric scales per person (P< 0.001 for ali). However, no association was found between the change in cytokine levels and the change in scores. induced by omega-3, on the assessed scales (P> 0.730). Summary Cytokine levels are not associated with PTSD severity or with improvement in PTSD symptomatology. At the same time, sertraline therapy supplemented with omega-3 seemed to reduce the severity of PTSD symptoms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA