Naslov
The role of insulin-like growth factor 2 and its receptors in human tumors

Autori
Pavelić, Krešimir ; Buković, Damir ; Pavelić, Jasminka

Izvornik
Molecular Medicine (1076-1551) 8 (2002); 881-780

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IGF2; IGF1 and 2 receptor; tumor

Sažetak
Insulin-like growth factor 2 (IGF2) is important for normal development and growth of an organism. In humans it is encoded by 11p15.5 paternally expressed-imprinted gene. It binds at least two different types of receptors: IGF type 1 (IGF1R) and IGF1/mannose 6-phosphate receptors (IGF2R/M6P). Ligand binding to IGF1R provokes mitogenic and antiapoptotic effects. IGF2R/M6P has tumor suppressor function - it mediates IGF 2 degradation. When the IGF2 gene/protein is overexpressed, mostly as a consequence of loss of heterozygosity resulting in paternal allele duplication (LOH) or by loss of imprinting (LOI), it is involved in the development and progression of many tumors and overgrowth syndromes by autocrine or paracrine mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA