Naslov
Friedel-Crafts acylations in ball-mill

Autori
Đud, Mateja ; Štrukil, Vjekoslav ; Jušinski, Iva ; Gracin, Davor ; Margetić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Skup
Stručni posjet, Hefei University

Mjesto i datum
Hefei, Kina, 04.05.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
organic synthesis; green chemistry; mechanochemistry; Friedel-Crafts

Sažetak
Friedel-Crafts acylation reactions were exploited in the preparation of aromatic ketones. For this purpose, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents, milling support, frequency of milling, size and number of milling balls, solvents for liquid assisted grinding were studied to establish the optimal reaction conditions. To explore the scope of the reaction, different aromatic hydrocarbons were used in conjuction with anhydrides and acyl halides. It was shown that certain FC reactive aromatics could be effectively functionalized by FC acylations carried out in ball-milling conditions without the presence of solvent. Some aspects of reaction mechanism were also explored by in situ reaction monitoring by Raman spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA