Naslov
Colocalization of Galectin-1 and Osteopontin in mouse uterus during early pregnancy

Autori
Šućurović, Sandra ; Nikolić, Tamara ; Mulac-Jeričević, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Molecules of life / - , 2015

Skup
FEBS3+ Meeting

Mjesto i datum
Portorož, Slovenija, 16.09.2015. - 19.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Pregnancy ; Galectin-1 ; Osteopontin ; NK cells

Sažetak
Pregnancy is highly regulated event in which endocrine, immune and metabolic systems co-operate in order to sustain life. Galectin-1 (Gal-1) is a glycoprotein found in endometrium during pregnancy. Important role of this glycoprotein in early pregnancy was established in study with Gal-1 knockout mice ; those mice exhibit high rate of fetal loss. Further, detail analyses of Gal-1 function during pregnancy have shown its role in angiogenic modulation, immune response and placental development. Placental development is also under control of specific population of natural killer (NK) cells known as uterine NK cells (uNK). As it known, some of uNK cells specifically recruit to placental attachment sites where intensive formation of new maternal blood vessels takes place. Subpopulation of uNK cells express osteopontin (OPN). Osteopontin is an Arg-Gly-Asp (RGD) containing integrin-binding glycoprotein postulated to regulate cell adhesion and invasion in many normal and pathological conditions. During peri-implantation period endometrium becomes structurally and functionally segregated tissue divided to mesometrial and antimesometrial pole. Our analysis has shown that during decidualization Gal-1 is localized in the stromal cells at the antimesometrial and mesometrial side. Additionally, OPN positive cells are present at mesometrial side of uterus during decidualization. This study was undertaken to analyze the spatial relationship between OPN and Gal-1 expression in mouse uterus during early pregnancy. Analysis of the cell type expressing Gal-1 will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA