Naslov
Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC)

Autori
Lučin, Ksenija ; Avirović, Manuela ; Matušan Ilijaš, Koviljka ; Cerović, Robert ; Juretić, Mirna ; Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pathology - breaking barriers in medicine ; Virchows Archiv / - , 2015, S89-S89

Skup
27th European Congress of Pathology

Mjesto i datum
Beograd, Srbija, 05.-09. September

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Osteopontin; Squamous Cell Carcinoma; Tumor associated macrophages

Sažetak
Objective: Osteopontin (OPN) is a glycoprotein involved in progression of many carcinomas, including oral squamous cell carcinoma (OSCC). It is synthesized by a variety of epithelial and mesenchymal cell types, including macrophages. Recently, a distinct activities of OPN from stromal and parenchymal tumor cells has been proposed. The aim of this study was to evaluate the expression of osteopontin in tumor-associated macrophages (TAMs) from OSCC tissue and to determine its possible prognostic significance. Method: The expression of OPN was immunohistochemicaly analyzed in TAMs from 86 OSCC and compared with clinicopathological variables. The staining intensity was semi-quantitatively assessed as high, moderate and low. Results: Diffusecytoplasmic positivity for OPN in infiltrating TAMs was classified as high in 21 patients, moderate in 47 patients, and low in 14 patients ; OPN+ macrophages were absent in 4 patients. Strong OPN expression in TAMs was associated with low invasive front grade (p < 0.006), low level of inflammatory response ( p< 0.018), and a better disease specific survival (p= 0.009). Expression patterns were not asso- ciated with pTstage (p= 0.28), lymph node status ( p= 0.21), nor with the WHO clinical stage (p =0.41). Conclusion: In OSCC macrophage-derived OPN probably has a different function compared with OPN secreted from tumor cells.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
(poster, međunarodna recenzija, sažetak, znanstveni)

POVEZANOST RADA