Naslov
Physiological Role of IL-15 and IL-18 at the Maternal-Fetal Interface (CC)

Autori
Laškarin, Gordana ; Štrbo, Nataša ; Bogović Crnčić, Tatjana ; Juretić, Koraljka ; Ledee Bataille, Nathalie ; Chaouat, Gerard ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Immunology of Pregnancy. Chem Immunol Allergy. (1660-2242) Vol. 89(Current Contents)

Urednik/ci
Markert U.R.

Izdavač
Karger Publishers

Grad
Basel

Godina
2005

Raspon stranica
10-25

ISBN
978-3-8055-7970-4

Ključne riječi
interleukin-15, interleukin-18, stanice NK, trudnoća
(interleukin-15, interleukin-18, NK cells, pregnancy)

Sažetak
Here, we review recent studies about two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate immunity and both Th1- and Th2-driven immune responses depending of cytokine milieu. We addressed possible role of these two cytokines in induction of the IFN-gamma production as a key molecule in vascular remodeling during early pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA