Naslov
Malnutrition in patients with chronic GVHD

Autori
Bassim, Carol W. ; Fassil, Hareya ; Dobbin, Marnie ; Steinberg, Sethm ; Baird, Kristin ; Cole, Kristen ; Joe, Galen O. ; Comis, Leora E. ; Mitchell, Sandra A. ; Grković, Lana ; Edwards, Dean ; Mays, Jacqueline W. ; Cowen, Edward W. ; Pulanić, Dražen ; Williams, Kirsten M. ; Gress, Ronald, E. ; Pavletić, Steven Živko

Izvornik
Bone marrow transplantation (Basingstoke) (0268-3369) 49 (2014), 10; 1300-1306

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
malnutrition ; chronic GVHD

Sažetak
Malnutrition is a known complication of chronic GVHD (cGVHD), but has not been well described in the context of organ-specific manifestations and the recent National Institutes of Health (NIH) criteria. Here, 210 cGVHD patients were analyzed, in a cross-sectional study design, for demographics, transplant-related history, clinical assessments, symptoms, function, quality-of-life, laboratory values and survival in order to determine their associations with nutritional status. Most patients had long- standing, moderate or severe cGVHD and had failed many lines of therapy. Twenty-nine percent (60/210) of subjects were malnourished, using the subjective Patient-Generated Subjective Global Assessment (PG-SGA) questionnaire and evaluation. No demographic or transplant characteristics were associated with malnutrition ; cGVHD of the lungs, gastrointestinal (GI) tract and mouth, NIH global score, cGVHD symptoms, worse functioning, low albumin, poorer survival and low BMI were associated with malnutrition. A predictive model was developed from all variables of significance: cGVHD of the lungs, GI tract, mouth and BMI accurately predicted 84.2% of malnourished patients as well as 87.2% of well-nourished patients. The PG-SGA questionnaire may be a useful tool in diagnosing nutritional deficits in cGVHD patients undergoing one-time evaluations. Longitudinal prospective studies should assess the utility of nutritional support interventions in cGVHD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA