Naslov
Active thrombopoiesis is associated with worse severity and activity of chronic GVHD

Autori
Bat, Taha ; Steinberg, Seth M. ; Childs, Richard ; Calvo, Katherine R. ; Barrett, A. John ; Battiwalla, Minoo ; Baird, Kristin ; Zhang, Dan ; Pulanić, Dražen ; Dunbar, Cynthia E. ; Pavletić, Steven Z.

Izvornik
Bone marrow transplantation (Basingstoke) (0268-3369) 48 (2013), 12; 1569-1573

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chronic GVHD ; NIH score ; platelets ; AIPN

Sažetak
Chronic graft-versus-host disease (cGvHD) is a major complication of allogeneic hematopoietic stem cell transplantation. Post-transplant thrombocytopenia in patients with cGvHD has been associated with poor outcome and its etiology is unclear. We investigated whether thrombopoiesis, assessed via measurement of the absolute immature platelet number (AIPN) in the blood, is impaired in cGVHD, and whether the level of thrombopoiesis correlates with the severity and activity of cGvHD as assessed via the NIH organ scoring system. We utilized a cohort of 110 well-characterized cGVHD patients, including 83 (75%) with severe cGVHD per NIH global score. Higher AIPN was associated with active therapeutic intent (p=0.026), lower Karnofsky score (p=0.0013), worse joint/fascia cGVHD (p=0.0005) and worse skin cGVHD (p=0.0044). AIPN correlated with platelet counts and was not correlated with ANC, WBC, CRP, ALC, albumin, total and average NIH scores, or number of prior systemic therapies. AIPN values for cGvHD patients substantially overlapped those of the normal population. Higher AIPN, as marker of active thrombopoiesisis, was associated with worse severity and activity of cGVHD, especially skin and joints/fascia manifestations. Among patients with stable moderate or severe cGVHD, there was no evidence of hypo production of platelets. Future studies should further investigate the role of thrombopoiesis in cGVHD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA