Naslov
Comparison of fecal calprotectin and CRP in pediatric inflammatory bowel disease

Autori
Linarić Irena ; Obuljen Jasna ; Margetić Sandra ; Mišak Z ; Hojsak I ; Žižić Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica / Šimundić Ana-Maria - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu/Medicinska naklada, 2012, A146-A146

Skup
2nd European Joint Congress of EFLM and UEMS and 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine (CSMBLM): Laboratory Medicine at the Clinical Interface

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
calprotectin C-reactive protein; inflammatory bowel disease; pediatric patients

Sažetak
Background: The aim of the study was to evaluate the diagnostic accuracy of C-reactive protein (CRP) and fecal calprotectin (FC) as markers of inflammatory bowel disease (IBD) in pediatric patients. Materials and methods: The study included 66 pediatrics patients ; 41 patients with IBD (confirmed by colonoscopy as the gold standard) and 25 patients with excluded IBD (non-IBD). The serum concentrations of CRP were measured by an immunoturbidimetric high sensitive latex CRP assay (Beckman Coulter, AU 400 analyzer). The concentrations of FC were measured with commercially available enzyme-linked immunosorbent assay (Calprest, Eurospital). Results: The medians (95% confidence interval (95%CI) ; interquartile range (IQR)) of both markers were significantly higher (P < 0.001) in IBD pediatric patients: CRP 8.7 mg/L (4.4- 16.0 ; 2.7-20.6) and FC 368.0 μg/g (234.0-457.0 ; 215.8-559.0) compared with non-IBD patients (CRP 0.3 mg/L ; (0.2-0.6 ; 0.2-0.7) and FC 15.6 μg/g (15.6-17.0 ; 15.6-20.8). However, the receiver operating characteristic (ROC) analysis showed significantly higher diagnostic accuracy (P = 0.039) of FC (area under curve (AUC) of 0.977 ; 95%CI = 0.905-0.998, sensitivity (Se) of 90.2% ; 95%CI = 76.9-97.3, specificity (Sp) of 100% ; 95%CI = 86.3-100.0, likelihood ratios LR- 0.09 and LR+ 22.6 at optimal cut-off value of 56 μg/g) compared with those of CRP (AUC = 0.903 ; 95%CI = 0.805- 0.962, Se = 75.6% (95%CI = 59.7-87.6), Sp = 96.0% (95%CI = 79.6-99.9), LR- 0.25 and LR+ 18.9 at optimal cut off value of 2.6 mg/L). Conclusion: Although both markers, CRP and fecal calprotectin, can be used for estimating mucosal inflammation in pediatric IBD patients, FC showed a higher diagnostic accuracy in discriminating between IBD and non-IBD pediatric patients with better sensitivity, specificity and likelihood ratios.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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