Naslov
Serum adipokine profile and adiponectin gene expression in neck adipose tissue in premenopausal and postmenopausal women

Autori
Pandzic Jaksic, Vlatka ; Grizelj, Danijela ; Boscic, Drago ; Ajduk, Marko ; Kelava, Tomislav ; Grcevic, Danka ; Marusic, Maruska ; Kusec, Rajko ; Jaksic, Ozren

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Endocrine Abstracts / - : BioScientifica, 2015, EP638-EP638

Skup
ECE 2015

Mjesto i datum
Dublin, Irska, 16.05.2015. - 20.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adipokines; adiponectin; adipose tissue; neck

Sažetak
Adipokines are an important contributor to the circulatory milieu of the body. The spectrum of adipokines changes as dysfunctional features of adipose tissue develop and the menopause is a time when an impairment of metabolic balance appears. The aim of this study was to examine several serum adipokines and adiponectin gene expression in subcutaneous and deep neck adipose tissue in women. Samples of serum, subcutaneous and deep neck adipose tissue were taken in 41 (12 premenopausal and 29 postmenopausal) women undergoing routine thyroid or vascular surgery. Serum adiponectin, leptin, omentin-1, monocyte chemoattractant protein-1 (MCP-1), fibroblast growth factor 21 (FGF21), retinol binding protein 4 (RBP4), insulin, glucose, triglycerides, HDL-cholesterol and C-reactive protein were determined. HOMA-IR was calculated and anthropometric measurements were performed. Adiponectin gene expression in adipose tissue samples was analysed by RQ–PCR method. Serum adiponectin and omentin-1 were negatively and leptin was positively associated with body weight, BMI and waist and neck circumference. RBP4 correlated with waist circumference and triglycerides. Leptin also was associated positively and omentin-1 negatively with triglycerides. FGF21 correlated with glucose and HDL-cholesterol. Omentin-1 negatively correlated with RBP4 and positively with serum adiponectin. Both serum adiponectin and omentin-1 were negatively associated with leptin. MCP-1 correlated only with RBP4. FGF21 didn’t correlate with other adipokines. Subcutaneous and deep adiponectin gene expressions were negatively associated with insulin, HOMA-IR and RBP4 but positively with omentin-1. Comparisons between premenopausal and postmenopausal group yielded significant differences in insulin, HOMA-IR, MCP-1 and RBP4. These results confirm multiple associations of various adipokines with metabolic parameters and secretory features of the neck adipose tissue depot. However, they also suggest that some adipokines cluster in specific profiles with potential particular biologic functions that should be further elucidated.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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