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Pregled bibliografske jedinice broj: 818514

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry

Sveinbjornsson, Gardar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Kristinsson, Karl G.; Gottfredsson, Magnus; Barrett, Jeffrey C.; Gudmundsson, Larus J.; Blondal, Kai; Gylfason, Arnaldur; Gudjonsson, Sigurjon Axel et al.
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry // Nature genetics, 48 (2016), 3; 318-322 doi:10.1038/ng.3498 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 818514 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry

Autori
Sveinbjornsson, Gardar ; Gudbjartsson, Daniel F. ; Halldorsson, Bjarni V. ; Kristinsson, Karl G. ; Gottfredsson, Magnus ; Barrett, Jeffrey C. ; Gudmundsson, Larus J. ; Blondal, Kai ; Gylfason, Arnaldur ; Gudjonsson, Sigurjon Axel ; Helgadottir, Hafdis T. ; Jonasdottir, Adalbjorg ; Jonasdottir, Aslaug ; Karason, Ari ; Bulat Kardum, Ljiljana ; Knežević, Jelena ; Kristjansson, Helgi ; Kristjansson, Mar ; Love, Arthur ; Luo, Yang ; Magnusson, Olafur T. ; Sulem, Patrick ; Kong, Augustine ; Masson, Gisli ; Thorsteinsdottir, Unnur ; Dembic, Zlatko ; Nejentsev, Sergey ; Blondal, Thorsteinn ; Jonsdottir, Ingileif ; Stefansson, Kari

Izvornik
Nature genetics (1061-4036) 48 (2016), 3; 318-322

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HLA class II ; tuberculosis ; variants

Sažetak
Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2, 636 Icelanders for association with tuberculosis (8, 162 cases and 277, 643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))-both located between HLA-DQA1 and HLA-DRB1-and a missense variant encoding p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14). We replicated association of these variants with PTB in samples of European ancestry from Russia and Croatia (P < 5.9 × 10(-4)). These findings show that the HLA class II region contributes to genetic risk of tuberculosis, possibly through reduced presentation of protective M. tuberculosis antigens to T cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Zlatko Dembić (autor)

Avatar Url Ljiljana Bulat-Kardum (autor)

Avatar Url Jelena Knežević (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Sveinbjornsson, Gardar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Kristinsson, Karl G.; Gottfredsson, Magnus; Barrett, Jeffrey C.; Gudmundsson, Larus J.; Blondal, Kai; Gylfason, Arnaldur; Gudjonsson, Sigurjon Axel et al.
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry // Nature genetics, 48 (2016), 3; 318-322 doi:10.1038/ng.3498 (međunarodna recenzija, članak, znanstveni)
Sveinbjornsson, G., Gudbjartsson, D., Halldorsson, B., Kristinsson, K., Gottfredsson, M., Barrett, J., Gudmundsson, L., Blondal, K., Gylfason, A. & Gudjonsson, S. (2016) HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature genetics, 48 (3), 318-322 doi:10.1038/ng.3498.
@article{article, author = {Sveinbjornsson, Gardar and Gudbjartsson, Daniel F. and Halldorsson, Bjarni V. and Kristinsson, Karl G. and Gottfredsson, Magnus and Barrett, Jeffrey C. and Gudmundsson, Larus J. and Blondal, Kai and Gylfason, Arnaldur and Gudjonsson, Sigurjon Axel and Helgadottir, Hafdis T. and Jonasdottir, Adalbjorg and Jonasdottir, Aslaug and Karason, Ari and Bulat Kardum, Ljiljana and Kne\v{z}evi\'{c}, Jelena and Kristjansson, Helgi and Kristjansson, Mar and Love, Arthur and Luo, Yang and Magnusson, Olafur T. and Sulem, Patrick and Kong, Augustine and Masson, Gisli and Thorsteinsdottir, Unnur and Dembic, Zlatko and Nejentsev, Sergey and Blondal, Thorsteinn and Jonsdottir, Ingileif and Stefansson, Kari}, year = {2016}, pages = {318-322}, DOI = {10.1038/ng.3498}, keywords = {HLA class II, tuberculosis, variants}, journal = {Nature genetics}, doi = {10.1038/ng.3498}, volume = {48}, number = {3}, issn = {1061-4036}, title = {HLA class II sequence variants influence tuberculosis risk in populations of European ancestry}, keyword = {HLA class II, tuberculosis, variants} }
@article{article, author = {Sveinbjornsson, Gardar and Gudbjartsson, Daniel F. and Halldorsson, Bjarni V. and Kristinsson, Karl G. and Gottfredsson, Magnus and Barrett, Jeffrey C. and Gudmundsson, Larus J. and Blondal, Kai and Gylfason, Arnaldur and Gudjonsson, Sigurjon Axel and Helgadottir, Hafdis T. and Jonasdottir, Adalbjorg and Jonasdottir, Aslaug and Karason, Ari and Bulat Kardum, Ljiljana and Kne\v{z}evi\'{c}, Jelena and Kristjansson, Helgi and Kristjansson, Mar and Love, Arthur and Luo, Yang and Magnusson, Olafur T. and Sulem, Patrick and Kong, Augustine and Masson, Gisli and Thorsteinsdottir, Unnur and Dembic, Zlatko and Nejentsev, Sergey and Blondal, Thorsteinn and Jonsdottir, Ingileif and Stefansson, Kari}, year = {2016}, pages = {318-322}, DOI = {10.1038/ng.3498}, keywords = {HLA class II, tuberculosis, variants}, journal = {Nature genetics}, doi = {10.1038/ng.3498}, volume = {48}, number = {3}, issn = {1061-4036}, title = {HLA class II sequence variants influence tuberculosis risk in populations of European ancestry}, keyword = {HLA class II, tuberculosis, variants} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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