Naslov
Genetska predispozicija za različite oblike spondiloartritisa
(Genetic predisposition for various forms of spondyloarthritis)

Autori
Lamot, Lovro ; Vidović, Mandica ; Perica, Marija ; Bukovac Tambić, Lana ; Harjaček, Miroslav ;

Izvornik
Reumatizam (0374-1338) 61 (2014), 1; 23-31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
juvenilni spondiloartritis
(juvenile spondyloarthritis)

Sažetak
In addition to the long-established association of HLA-B27 antigen and spondyloarthritis, several studies have shown a similar association with HLA-B7 antigen. But since the whole MHC region carries less than half of the risk for the development of the disease, the main goal of many recently performed researches, which implemented various high-throughput methods, was to discover the influence of genes outside the MHC region on disease development. The results showed that genes closely linked to spondyloarthritis participate in antigen processing and coding of various cytokines. This can lead to the conclusion that diseases from the spondyloarthritis group are polygenic, affected by both autoinflammatory and autoimmune mechanisms.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA