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Pregled bibliografske jedinice broj: 816937

Glycosilation profile of immunoglobulin G in moderate kidney dysfunction

Barrios, Clara; Zierer, Jonas; Gudelj, Ivan; Štambuk, Jerko; Ugrina, Ivo; Rodríguez, Eva; Soler, María José; Pavić, Tamara; Šimurina, Mirna; Keser, Toma et al.
Glycosilation profile of immunoglobulin G in moderate kidney dysfunction // XXIII International Symposium on Glycoconjugates (GLYCO 23), Glycoconjugate Journal 32 (2015) (5) 173-312
Split, Hrvatska, 2015. str. 264-264 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 816937 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycosilation profile of immunoglobulin G in moderate kidney dysfunction

Autori
Barrios, Clara ; Zierer, Jonas ; Gudelj, Ivan ; Štambuk, Jerko ; Ugrina, Ivo ; Rodríguez, Eva ; Soler, María José ; Pavić, Tamara ; Šimurina, Mirna ; Keser, Toma ; Pučić-Baković, Maja ; Mangino, Massimo ; Pascual, Julio ; Spector, Tim D. ; Lauc, Gordan ; Menni, Cristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIII International Symposium on Glycoconjugates (GLYCO 23), Glycoconjugate Journal 32 (2015) (5) 173-312 / - , 2015, 264-264

Skup
XXIII International Symposium on Glycoconjugates (GLYCO 23)

Mjesto i datum
Split, Hrvatska, 15.09.2015. - 20.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
clinical nephrology ; glycosylation ; renal function decline

Sažetak
Glycans constitute the most abundant and diverse form of the post-translational modifications. Here we explore the associations between IgG glycans and renal function in 3274 individuals from TwinsUK. We analyzed the correlation between renal function measured as eGFR and 76N-glycan traits using linear regressions adjusting for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. 14 glycan traits were associated with renal function in the discovery sample (P<6.5×10−4) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation and level of bisecting N- acetylglucosamine (GlcNAc) of the IgG glycans. This is the first study to show the role of IgG glycosylation in assessing kidney function. These results provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Biologija, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Profili:

Avatar Url JERKO ŠTAMBUK (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Toma Keser (autor)

Avatar Url Tamara Štambuk (autor)

Avatar Url Ivan Gudelj (autor)

Avatar Url Maja Pučić Baković (autor)

link.springer.com

Citiraj ovu publikaciju:

Barrios, Clara; Zierer, Jonas; Gudelj, Ivan; Štambuk, Jerko; Ugrina, Ivo; Rodríguez, Eva; Soler, María José; Pavić, Tamara; Šimurina, Mirna; Keser, Toma et al.
Glycosilation profile of immunoglobulin G in moderate kidney dysfunction // XXIII International Symposium on Glycoconjugates (GLYCO 23), Glycoconjugate Journal 32 (2015) (5) 173-312
Split, Hrvatska, 2015. str. 264-264 (poster, međunarodna recenzija, sažetak, znanstveni)
Barrios, C., Zierer, J., Gudelj, I., Štambuk, J., Ugrina, I., Rodríguez, E., Soler, M., Pavić, T., Šimurina, M. & Keser, T. (2015) Glycosilation profile of immunoglobulin G in moderate kidney dysfunction. U: XXIII International Symposium on Glycoconjugates (GLYCO 23), Glycoconjugate Journal 32 (2015) (5) 173-312.
@article{article, author = {Barrios, Clara and Zierer, Jonas and Gudelj, Ivan and \v{S}tambuk, Jerko and Ugrina, Ivo and Rodr\'{\i}guez, Eva and Soler, Mar\'{\i}a Jos\'{e} and Pavi\'{c}, Tamara and \v{S}imurina, Mirna and Keser, Toma and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Mangino, Massimo and Pascual, Julio and Spector, Tim D. and Lauc, Gordan and Menni, Cristina}, year = {2015}, pages = {264-264}, keywords = {clinical nephrology, glycosylation, renal function decline}, title = {Glycosilation profile of immunoglobulin G in moderate kidney dysfunction}, keyword = {clinical nephrology, glycosylation, renal function decline}, publisherplace = {Split, Hrvatska} }
@article{article, author = {Barrios, Clara and Zierer, Jonas and Gudelj, Ivan and \v{S}tambuk, Jerko and Ugrina, Ivo and Rodr\'{\i}guez, Eva and Soler, Mar\'{\i}a Jos\'{e} and Pavi\'{c}, Tamara and \v{S}imurina, Mirna and Keser, Toma and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Mangino, Massimo and Pascual, Julio and Spector, Tim D. and Lauc, Gordan and Menni, Cristina}, year = {2015}, pages = {264-264}, keywords = {clinical nephrology, glycosylation, renal function decline}, title = {Glycosilation profile of immunoglobulin G in moderate kidney dysfunction}, keyword = {clinical nephrology, glycosylation, renal function decline}, publisherplace = {Split, Hrvatska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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