Naslov
IAEA randomised study on optimization of treatment of locally advanced NSCLC using radiotherapy and chemotherapy

Autori
Jeremić, Branislav ; Fidarova, Elena ; Sharma, V. ; Faheem, M. ; Ameira, A. ; Nasr, Ben Amar ; Frobe, Ana ; Lau, F.N. ; Brincat, S. ; Jones, G.

Izvornik
Radiotherapy and oncology (0167-8140) 116 (2015), 1; 21-26

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NSCLC ; locally advanced nonsmall cell lung canc ; radiotherapy ; chemotherapy ; randomized trial ; International Atomic Energy Agency

Sažetak
O optimize palliation in incurable locally advanced non-small cell lung cancer (NSCLC), the International Atomic Energy Agency conducted a prospective randomized study (NCT00864331) comparing protracted palliative radiotherapy (RT) course with chemotherapy (CHT) followed by short-course palliative RT. Treatment-naive patients with histologically confirmed NSCLC, stage IIIA/IIIB, received either 39 Gy in 13 fractions as RT alone (arm A, n = 31) or 2–3 platinum-based CHT cycles followed by 10 Gy in a single fraction or 16 Gy in 2 fractions separated by one week (arm B, n = 34). Primary outcome was overall survival. Treatment groups were balanced with respect to various variables. Median survival for all 65 patients was 8 months, while median survival was 7.1 and 8.1 months for the two arms, respectively (log-rank p = 0.4 by study arm, and p = 0.6 by Cox regression and stratified by country and sub-stage). One and three year survival rates for the two arms were 29%, and 9% and 41%, and 6%, respectively. There were no differences in any of the following endpoints: any failure, local failure, regional failure, contralateral thoracic failure, and distant failure between the two arms. High-grade (⩾3) toxicity was similar between the two arms. Symptoms, adverse events of any kind, KPS and body-mass index, were not different during treatment and during follow-up. There was no grade 5 toxicity. This incomplete and underpowered trial only hinted similar outcome between the treatment arms. Therefore, combined CHT-RT can perhaps be considered, in limited resource setting, where access to RT remains inadequate.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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