Naslov
Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula

Autori
Grgić, Tihomir ; Grgić, Dora ; Drmić, Domagoj ; Zenko Sever, Anita ; Petrović, Igor ; Sučić, Mario ; Kokot, Antonio ; Kliček, Robert ; Sever, Marko ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
European journal of pharmacology (0014-2999) 780 (2016); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157 ; colon ; colovesical fistula ; healing ; rats

Sažetak
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups. BPC 157, a stable gastric pentadecapeptide, has been used in clinical applications-specifically, in ulcerative colitis-and was successful in treating both external and internal fistulas. BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice. Controls simultaneously received an equivolume of saline (5.0ml/kg ip) or water only (12ml/rat/day). Assessment (i.e., colon and vesical defects, fistula leaking, fecaluria and defecation through the fistula, adhesions and intestinal obstruction as healing processes) took place on days 7, 14 and 28. Control colovesical fistulas regularly exhibited poor healing, with both of the defects persisting ; continuous fistula leakage ; fecaluria and defecation through the fistula ; advanced adhesion formation ; and intestinal obstruction. By contrast, BPC 157 given perorally or intraperitoneally and in µg- and ng-regimens rapidly improved the whole presentation, with both colon and vesical defects simultaneously ameliorated and eventually healed. The maximal instilled volume was continuously raised until it reached the values of healthy rats, there were no signs of fecaluria and no defecation through the fistula, there was counteraction of advanced adhesion formation or there was an intestinal obstruction. In conclusion, BPC 157 effects appear to be suited to inducing full healing of colocutaneous fistulas in rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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