Naslov
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients

Autori
Matijašić, Mario ; Meštrović, Tomislav ; Perić, Mihaela ; Čipčić Paljetak, Hana ; Panek, Marina ; Vranešić Bender, Darija ; Ljubas Kelečić, Dina ; Krznarić, Željko ; Verbanac, Donatella

Izvornik
International journal of molecular sciences (1422-0067) 17 (2016), 4; 578-600

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
gut microbiota ; inflammatory bowel disease (IBD) ; dietary interventions ; probiotics ; fecal microbiota transplantation (FMT) ; nematodes

Sažetak
The healthy intestine represents a remarkable interface where sterile host tissues come in contact with gut microbiota, in a balanced state of homeostasis. The imbalance of gut homeostasis is associated with the onset of many severe pathological conditions, such as inflammatory bowel disease (IBD), a chronic gastrointestinal disorder increasing in incidence and severely influencing affected individuals. Despite the recent development of next generation sequencing and bioinformatics, the current scientific knowledge of specific triggers and diagnostic markers to improve interventional approaches in IBD is still scarce. In this review we present and discuss currently available and emerging therapeutic options in modulating composition and metabolic activity of gut microbiota in patients affected by IBD. Therapeutic approaches at the microbiota level, such as dietary interventions alone or with probiotics, prebiotics and synbiotics, administration of antibiotics, performing fecal microbiota transplantation (FMT) and the use of nematodes, all represent a promising opportunities towards establishing and maintaining of well-being as well as improving underlying IBD symptoms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA