Naslov
Functional neuroanatomy of nociception and pain

Autori
Hladnik, Ana ; Bicanic, Ivana ; Petanjek, Zdravko

Izvornik
Periodicum biologorum (0031-5362) 117 (2015), 2; 195-204

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PHANTOM LIMB PAIN; NEUROPATHIC PAIN; PERIPHERAL MECHANISMS; MOLECULAR-MECHANISMS; DESCENDING CONTROL; OPIOID ANALGESIA; C-NOCICEPTORS; PHYSICAL PAIN; MODULATION; HYPERALGESIA

Sažetak
Pain is a complex sensory state based on the integration of a variety of nociceptive inputs processed centrally through many parallel and overlapping neural systems. The traditional anatomical concept implies that nociceptive information is dominantly used to generate and regulate perception of pain through one major sensory pathway. It becomes recognized that experiencing the affective component of the pain is at least as important as perception. Also, nociceptive information is strongly influencing brain centers for regulating homeostasis. So, understanding neuroanatomical organization of central processing of nociceptive information is of great clinical importance. There is an attempt to simplify this complex set of interacting networks to a core set of brain regions or a generalizable pain signature. Herewith we wish to give a short overview of recent advances by presenting principles about neuroanatomical organization for processing various aspects of nociceptive inputs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA