Naslov
Clinical overview of insulin glargine 300 units/mL (TOUJEO®)

Autori
Duvnjak, Lea ; Bulum, Tomislav ; Božek, Tomislav

Izvornik
Diabetologia Croatica (0351-0042) 44 (2015); 31-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
new insulin glargine 300 units/mL; constant and prolonged PK/PD profile; type 1 and type 2 diabetes mellitus

Sažetak
New insulin glargine 300 units/mL (Gla-300) is a basal insulin that provides the same number of units as Gla-100 in a third of the volume. Compared with Gla-100, Gla-300 has shown more constant and prolonged pharmacokinetic (PK)/pharmacodynamic (PD) profiles. Gla-300 has been shown to achieve similar glycemic control with less nocturnal hypoglycemia compared with Gla-100, and lower hypoglycemia at any time of day. The EDITION clinical program also provides evidence for less weight gain with Gla-300 than with Gla-100. The PK/PD profiles of Gla-300 may allow more flexibility in the timing of doses. Based on these findings, Gla-300 could be optimal treatment option for a range of people with type 1 and type 2 diabetes mellitus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA