Naslov
Atypical Spitz Tumor of Uncertain Biologic Potential with Inopportune Localization in a 7-year-old Boy

Autori
Glavan, Nedeljka ; Zamolo, Gordana ; Katunarić, Miljenko ; Jonjić, Nives

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 23 (2015); 224-227

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, ostalo

Ključne riječi
Spitz; melanoma; NRAS

Sažetak
Importance: Atypical Spitz tumors are rare melanocytic lesions with an uncertain malignant potential. Atypical Spitz tumors have overlapping histological features of both benign typical Spitz nevi and spitzoid melanoma ; accordingly generate controversy in the diagnosis and management. Due to rarity of these lesions the appropriate risk evaluation and strategies of treatment remain to be determined. Observations: Here we present a case of a 7-year old boy with previously traumatized, brown nodule on his nose. Consultation of several dermatopathologist revealed the lesion as high-risk atypical Spitz tumor of uncertain malignant potential. To evaluate the possible malignant potential of the lesion and for decision of further therapeutic approach BRAF and NRAS mutation analysis were done and a wild type was confirmed. Concerning the results of molecular analysis, as well as the surgical inopportune localization in child the reduced re- excision was performed. Conclusions and Relevance: The aggressive behaviour of atypical Spitz tumors is one of the biggest challenges in modern skin pathology. The newer techniques may provide information that can be helpful in evaluating the possible malignant potential of the lesion and for decision of further therapeutic approach.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA