Naslov
Ribosomal Biogenesis Stress and p53 Activation

Autori
Volarević, Siniša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
International two-day workshop "RNA Biology meets Sleep and Circadian Rhythms"

Mjesto i datum
Gloucester, Ujedinjeno Kraljevstvo, 26.06.2014. - 27.06.2014

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
ribosomal biogenesis; p53

Sažetak
Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. I will discuss when, how and why p53 is activated upon ribosome biogenesis stress, and how perturbation of this critical regulatory interplay may impact disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA