Pregled bibliografske jedinice broj: 813408
Ribosomal proteins and p53 activation
Ribosomal proteins and p53 activation // INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses
Atena, 2014. str. 25-25 (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 813408 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Ribosomal proteins and p53 activation
Autori
Volarević, Siniša
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses
/ - Atena, 2014, 25-25
Skup
INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses
Mjesto i datum
Atena, Grčka, 23.04.2014. - 25.04.2014
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
p53; ribosomal proteins
Sažetak
Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. Our research interests focus on understanding the molecular basis of this checkpoint response and determining its role in pathogenesis of various diseases.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-1081347-0370 - Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo (Volarević, Siniša, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Siniša Volarević
(autor)
