Pregled bibliografske jedinice broj: 812966
EGFR activated cell mobility–A link to melanoma ulceration
EGFR activated cell mobility–A link to melanoma ulceration // Medical hypotheses, 85 (2015), 4; 498-499 doi:10.1016/j.mehy.2015.07.007 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 812966 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
EGFR activated cell mobility–A link to melanoma ulceration
Autori
Katunarić, Miljenko ; Zamolo, Gordana ; Jonjić, Nives
Izvornik
Medical hypotheses (0306-9877) 85
(2015), 4;
498-499
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Melanoma ulceration ; EGFR activity ; cell mobility
Sažetak
Melanoma ulceration is the third most powerful survival predictor in the analysis for the currently valid 2010 AJCC melanoma staging system. However, there is still no detailed explanation for melanoma ulceration mechanism. Although thicker tumors are more commonly ulcerated, ulceration is a factor that predicts the disease outcome independently of melanoma thickness. It is our hypothesis that EGFR activates melanoma cell mobility. Melanoma cells with increased mobility move through tissue in diverse direction. Cells moving toward the epithelium weaken the intercellular bonds between the cells causing the loss of epithelium and subsequently ulceration.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
