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Pregled bibliografske jedinice broj: 812470

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

Vahl, J. Christoph; Drees, Christoph; Heger, Klaus; Heink, Sylvia; Fischer, Julius C.; Nedjić, Jelena; Ohkura, Naganari; Morikawa, Hiromasa; Poeck, Hendrik; Schallenberg, Sonja et al.
Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool // Immunity, 41 (2014), 5; 722-736 doi:10.1016/j.immuni.2014.10.012 (međunarodna recenzija, članak, znanstveni)

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Naslov
Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

Autori
Vahl, J. Christoph ; Drees, Christoph ; Heger, Klaus ; Heink, Sylvia ; Fischer, Julius C. ; Nedjić, Jelena ; Ohkura, Naganari ; Morikawa, Hiromasa ; Poeck, Hendrik ; Schallenberg, Sonja ; Rieß, David ; Hein, Marco Y. ; Buch, Thorsten ; Polić, Bojan ; Schoenle, Anne ; Zeiser, Robert ; Schmitt-Graeff, Annette ; Kretschmer, Karsten ; Klein, Ludger ; Korn, Thomas ; Sakaguchi, Shimon ; Schmidt-Supprian, Marc

Izvornik
Immunity (1074-7613) 41 (2014), 5; 722-736

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Foxp3; TCR; Treg

Sažetak
Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become Treg cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inherent autoreactivity for Treg cell biology remains poorly defined. To address this open question, we genetically ablated the TCR of mature Treg cells in vivo. These experiments revealed that TCR-induced Treg lineage-defining Foxp3 expression and gene hypomethylation were uncoupled from TCR input in mature Treg cells. However, Treg cell homeostasis, cell-type-specific gene expression and suppressive function critically depend on continuous triggering of their TCR.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Bojan Polić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Vahl, J. Christoph; Drees, Christoph; Heger, Klaus; Heink, Sylvia; Fischer, Julius C.; Nedjić, Jelena; Ohkura, Naganari; Morikawa, Hiromasa; Poeck, Hendrik; Schallenberg, Sonja et al.
Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool // Immunity, 41 (2014), 5; 722-736 doi:10.1016/j.immuni.2014.10.012 (međunarodna recenzija, članak, znanstveni)
Vahl, J., Drees, C., Heger, K., Heink, S., Fischer, J., Nedjić, J., Ohkura, N., Morikawa, H., Poeck, H. & Schallenberg, S. (2014) Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool. Immunity, 41 (5), 722-736 doi:10.1016/j.immuni.2014.10.012.
@article{article, author = {Vahl, J. Christoph and Drees, Christoph and Heger, Klaus and Heink, Sylvia and Fischer, Julius C. and Nedji\'{c}, Jelena and Ohkura, Naganari and Morikawa, Hiromasa and Poeck, Hendrik and Schallenberg, Sonja and Rieß, David and Hein, Marco Y. and Buch, Thorsten and Poli\'{c}, Bojan and Schoenle, Anne and Zeiser, Robert and Schmitt-Graeff, Annette and Kretschmer, Karsten and Klein, Ludger and Korn, Thomas and Sakaguchi, Shimon and Schmidt-Supprian, Marc}, year = {2014}, pages = {722-736}, DOI = {10.1016/j.immuni.2014.10.012}, keywords = {Foxp3, TCR, Treg}, journal = {Immunity}, doi = {10.1016/j.immuni.2014.10.012}, volume = {41}, number = {5}, issn = {1074-7613}, title = {Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool}, keyword = {Foxp3, TCR, Treg} }
@article{article, author = {Vahl, J. Christoph and Drees, Christoph and Heger, Klaus and Heink, Sylvia and Fischer, Julius C. and Nedji\'{c}, Jelena and Ohkura, Naganari and Morikawa, Hiromasa and Poeck, Hendrik and Schallenberg, Sonja and Rieß, David and Hein, Marco Y. and Buch, Thorsten and Poli\'{c}, Bojan and Schoenle, Anne and Zeiser, Robert and Schmitt-Graeff, Annette and Kretschmer, Karsten and Klein, Ludger and Korn, Thomas and Sakaguchi, Shimon and Schmidt-Supprian, Marc}, year = {2014}, pages = {722-736}, DOI = {10.1016/j.immuni.2014.10.012}, keywords = {Foxp3, TCR, Treg}, journal = {Immunity}, doi = {10.1016/j.immuni.2014.10.012}, volume = {41}, number = {5}, issn = {1074-7613}, title = {Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool}, keyword = {Foxp3, TCR, Treg} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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