Naslov
Antiresorptivni lijekovi u liječenju osteoporoze
(Antiresorptive agents in the treatment of osteoporosis)

Autori
Novak Srđan

Izvornik
Reumatizam (0374-1338) 2 (2014); 89-94

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
antiresorptivni lijekovi; bisfosfonati; denosumab; liječenje; osteoporoza
(antiresorptive agents; bisphosphonates; denosumab; treatment)

Sažetak
The aim of drug treatment of osteoporosis is the balance between activity of osteoblasts and osteoclasts with aug- mentation of mineral bone density and decrease of fracture risk. Antiresorptive agents depress osteoclasts and diminish resorption of bone. They include bisphosphonates, selective estrogen receptor modulators (SERMs), denosumab, while hormone replacement therapy and calcitonin are mostly abandoned. By binding to hydroxyapatite crystals of bone surface bisphosphonates inhibit the resorption of bone and prevent vertebral and non-vertebral fractures. Denosumab is a monoclonal antibody which by hindering interaction between RANKL and RANK inhibits osteoclastogenesis and diminishes bone resorption in cortical and trabecular bones, thus significantly lessening fracture risk.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA