Naslov
Therapeutic monitoring of immunosuppressive drugs: Where do we stand?

Autori
Granić, Paula ; Lalić, Zdenka

Izvornik
Neurologia Croatica. Supplement (1331-5196) 61 (2012); 161-165

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
cyclosporine; everolimus; immunosuppressive drugs; mycophenolic acid; sirolimus; tacrolimus; therapeutic drug monitoring

Sažetak
In the first half of the 20th century, attempts at transplantation of organs were unsuccessful because there were no clear ideas about the processes of immune response. With the advances in immunology, immunosuppressive drugs were developed. Initially, it was thought that successful immunosuppression can be achieved only by achieving complete immunodeficiency. Today we are entering an era in which the aim of a standard combination therapy will be no more to suppress the immune system, but to modulate it. Eff ective, safe and cost-eff ective therapy requires dosage individualization based on therapeutic drug monitoring.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA