Pregled bibliografske jedinice broj: 810448
Unexpected meningeal reaction to pain in trigeminal region: association with calcitonin gene-related polypeptide
Unexpected meningeal reaction to pain in trigeminal region: association with calcitonin gene-related polypeptide // Journal of the Neurological Sciences 357 (2015) e90-e92
Santiago, Čile, 2015. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 810448 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Unexpected meningeal reaction to pain in trigeminal region: association with calcitonin gene-related polypeptide
Autori
Lacković, Zdravko ; Filipović, Boris ; Matak, Ivica ; Helyes, Zsuzsanna
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Journal of the Neurological Sciences 357 (2015) e90-e92
/ - , 2015
Skup
World Congress of Neurology 2015
Mjesto i datum
Santiago, Čile, 31.10.2015. - 05.11.2015
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
trigeminal pain; neurogenic inflammation; calcitonin gene-related peptide
Sažetak
Background: Recently we observed that two different types of pain: infraorbital nerve constriction injury (IONC) and facial formalin injection in rats (Filipović et al. Plos One 2012) are accompanied by dural neurogenic inflammation (DNI) characterized by extravasation of plasma proteins and inflammatory cells. This previously unknown phenomenon is specific only for trigeminal region, since peripheral types of pain like partial transection of the sciatic nerve (ScNT) and sciatic nerve constriction injury (SCI) are avoid of extravasation of lumbar or cranial dura (Filipović et al., J Neural Transmission 2004). Objective: To investigate possible association of pain induced DNI with calcitonin gene-related peptide (CGRP). Material and methods: We investigated third type of pain in trigeminal region: Freund adjuvant induced inflammation and pain in temporomandibular joint (TMJ) of rat. DNI was investigated by Evans blue-plasma protein extravasation, and cell histology. CGRP was investigated by immunohistochemistry and radioimmunoassay. Effect of several analgesics drugs (aspirin, morphine, sumatriptan) was tested as well Results: TMJ induced pain was accompanied by dural plasma proteins and inflammatory cells and increase in CGRP level in dura. Conclusion: In addition to IONC and facial formalin injection, TMJ induced pain is accompanied by neurogenic dural extravasation, as well. Pain induced DNI is associated with CGRP expression in meninges.
Izvorni jezik
Engleski
