Naslov
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Autori
Okbay A ; Baselmans BM ; De Neve JE ; ... ; Polašek, Ozren ; ... ; Kolčić, Ivana ; ... ; Cesarini, David

Izvornik
Nature genetics (1061-4036) 48 (2016); 3552-3552

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
personality ; genetic ; epidemiology

Sažetak
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298, 420), depressive symptoms (n = 161, 460), and neuroticism (n = 170, 911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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