Naslov
Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of posttraumatic stress disorder

Autori
Švob Štrac, Dubravka ; Kovačić Petrović, Zrnka ; Nikolac Perković, Matea ; Umolac, Danica ; Nedić Erjavec, Gordana ; Pivac, Nela

Izvornik
Stress (1025-3890) 19 (2016), 4; 362-373

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MAO ; Agitation ; psychotic symptoms ; PTSD severity ; CAPS scores ; PANSS scores

Sažetak
Posttraumatic stress disorder (PTSD), a disorder that develops following exposure to traumatic experience(s), is frequently associated with agitation, aggressive behavior and psychotic symptoms. Monoamine oxidase (MAO) degrades different biogenic amines and regulates mood, emotions and behavior, and has a role in the pathophysiology of various mental and neurodegenerative disorders. The aim of the study was to investigate the association between different symptoms occurring in PTSD (PTSD symptom severity assessed by the Clinician Administered PTSD Scale (CAPS), agitation and selected psychotic symptoms assessed by the Positive and Negative Syndrome Scale (PANSS)) and platelet MAOB activity and/or the genetic variants of MAOB rs1799836 and MAOA-uVNTR polymorphisms in 249 Croatian male veterans with PTSD. Associations were detected between platelet MAO-B activity and PTSD symptom severity, agitation and selected psychotic symptoms. Platelet MAO-B activity was associated with smoking but not with age. Regarding the most frequently evaluated polymorphisms in the MAOA and MAOB genes, genetic variants of MAOB rs1799836 and MAOA- uVNTR were not associated with agitation and selected psychotic symptoms in veterans with PTSD. A marginally significant association was found between MAOB rs1799836 polymorphism and severity of PTSD symptoms, but was not confirmed since carriers of the G or A allele of MAOB rs1799836 did not differ in their total CAPS scores. These findings suggest an association of platelet MAO-B activity, but a lack of association of MAOB rs1799836 and MAOA- uVNTR, with agitation and selected psychotic symptoms in ethnically homogenous Caucasians, matched for the combat experience, with chronic and current combat related PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA