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Pregled bibliografske jedinice broj: 809986

Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype.

Kulić, Ana; Dedić Plavetić, Natalija; Gamulin, Stjepan; Jakić- Razumović, Jasminka; Vrbanec, Damir; Sirotković- Skerlev, Maja
Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype. // Medical oncology, 33 (2016), 3; 23-28 doi:10.1007/s12032-016-0736-x (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 809986 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype.

Autori
Kulić, Ana ; Dedić Plavetić, Natalija ; Gamulin, Stjepan ; Jakić- Razumović, Jasminka ; Vrbanec, Damir ; Sirotković- Skerlev, Maja

Izvornik
Medical oncology (1357-0560) 33 (2016), 3; 23-28

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aggressive phenotype ; Breast cancer ; Prognosis ; Telomerase activity

Sažetak
Telomerase expression is an important mechanism of tumor unlimited replicative potential. The aim of this study was to evaluate prognostic impact of telomerase activity in breast cancer patients and to correlate telomerase activity with established prognostic factors. We analyzed tissue of 102 malignant breast lesions and 20 healthy breast tissues. Telomerase activity was determined by telomeric repeat amplification protocol assay. Telomerase activity was present in 77 (75.49 %) of 102 breast cancers. Telomerase activity in breast cancers was statistically significantly higher in comparison with the activity in normal breast tissue. The levels of telomerase activity were significantly positively correlated with tumor size, axillary nodal status, histological grade, HER-2/neu protein expression in tumor tissue and expression of the nuclear antigen Ki-67. A statistically significant negative correlation was found between the presence of ER and telomerase activity. There was no correlation between telomerase activity and concentration of PR or the age of patients. Kaplan-Meier analysis showed that patients with higher telomerase activity had significantly shorter 10-year disease-free survival (p < 0.0001) and 10-year overall survival (p < 0.0001) than those with lower telomerase activity. These results were confirmed by logistic regression analysis. Our results support the prognostic role of telomerase activity and its relationship with the more aggressive phenotype of breast cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1080058-0046 - KARCINOM DOJKE-MOLEKULARNE,GENETSKE I KLINIČKE KARAKTERISTIKE (Vrbanec, Damir, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Damir Vrbanec (autor)

Avatar Url Stjepan Gamulin (autor)

Avatar Url Jasminka Jakić-Razumović (autor)

Avatar Url Ana Kulić (autor)

Avatar Url Natalija Dedić-Plavetić (autor)

Avatar Url Maja Sirotković-Skerlev (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Kulić, Ana; Dedić Plavetić, Natalija; Gamulin, Stjepan; Jakić- Razumović, Jasminka; Vrbanec, Damir; Sirotković- Skerlev, Maja
Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype. // Medical oncology, 33 (2016), 3; 23-28 doi:10.1007/s12032-016-0736-x (međunarodna recenzija, članak, znanstveni)
Kulić, A., Dedić Plavetić, N., Gamulin, S., Jakić- Razumović, J., Vrbanec, D. & Sirotković- Skerlev, M. (2016) Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype.. Medical oncology, 33 (3), 23-28 doi:10.1007/s12032-016-0736-x.
@article{article, author = {Kuli\'{c}, Ana and Dedi\'{c} Plaveti\'{c}, Natalija and Gamulin, Stjepan and Jaki\'{c}- Razumovi\'{c}, Jasminka and Vrbanec, Damir and Sirotkovi\'{c}- Skerlev, Maja}, year = {2016}, pages = {23-28}, DOI = {10.1007/s12032-016-0736-x}, keywords = {Aggressive phenotype, Breast cancer, Prognosis, Telomerase activity}, journal = {Medical oncology}, doi = {10.1007/s12032-016-0736-x}, volume = {33}, number = {3}, issn = {1357-0560}, title = {Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype.}, keyword = {Aggressive phenotype, Breast cancer, Prognosis, Telomerase activity} }
@article{article, author = {Kuli\'{c}, Ana and Dedi\'{c} Plaveti\'{c}, Natalija and Gamulin, Stjepan and Jaki\'{c}- Razumovi\'{c}, Jasminka and Vrbanec, Damir and Sirotkovi\'{c}- Skerlev, Maja}, year = {2016}, pages = {23-28}, DOI = {10.1007/s12032-016-0736-x}, keywords = {Aggressive phenotype, Breast cancer, Prognosis, Telomerase activity}, journal = {Medical oncology}, doi = {10.1007/s12032-016-0736-x}, volume = {33}, number = {3}, issn = {1357-0560}, title = {Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype.}, keyword = {Aggressive phenotype, Breast cancer, Prognosis, Telomerase activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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