Naslov
ANTICOAGULANT PATHWAYS IN CANINE BABESIOSIS CAUSED BY BABESIA CANIS CANIS

Autori
Kuleš, Josipa ; Gotić, Jelena ; Mrljak, Vladimir ; Barić Rafaj, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 17th biennial Congress of the International Society for Animal Clinical Pathology / - , 2016, 83-83

Skup
17th biennial Congress of the International Society for Animal Clinical Pathology

Mjesto i datum
Cape Town, Južnoafrička Republika, 05.04.2016. - 09.04.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
babesiosis; hemostasis; anticoagulant pathway

Sažetak
Background. Canine babesiosis is a vector-borne disease caused by the hemoprotozoan parasites of the genus Babesia. A proinflammatory condition in babesiosis appears to influence endothelial activation and hemostatic activity. Among major anticoagulant mechanisms involved in the regulation of coagulation activation are antithrombin and protein C pathway. Protein C is activated through the receptors thrombomodulin and endothelial protein C receptor. Objective. The aim of this study was to determine changes in coagulation system components, particularly in anticoagulant pathways in canine babesiosis. Methods. In this study 25 dogs naturally infected with Babesia canis canis and 10 healthy dogs were included. Blood samples from dogs with babesiosis were taken at the day of admission before treatment with imidocarb dipropionate. Levels of thrombin-antithrombin complexes (TAT), activated protein C (APC) and endothelial protein C receptor (EPCR) were determined using a specific canine ELISA, and protein C (PC) activity was assessed using chromogenic substrate test. Results. Levels of TAT (median, range: 5.39 ng/ml, 4.52 – 6.46) and APC (median, range: 3.21 ng/ml, 1.48 – 4.45) were significantly higher in dogs with babesiosis compared to healthy dogs (p=0.007 and p=0.036, respectively). Conclusions. Parameters of anticoagulant pathways are altered in babesiosis. These findings indicate activation of coagulation system and increased thrombin generation.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA