Naslov
Twice weekly low dose interferon-beta-1a in relapsing-remitting multiple sclerosis

Autori
Debelić, Diana ; Jurjević, Anton ; Willheim, Ksenija ; Sepčić, Juraj

Izvornik
Acta Facultatis medicae Fluminensis (0065-1206) 26 (2001), 1-2; 13-17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
interferon-beta; multiple sclerosis

Sažetak
We present a randomized open-label study of interferon-beta-1a in 14 patients with relapsing-remitting multiple sclerosis. Interferon-beta-1a was administred in dose of 11 mg subcutaneously twice weekly for 12 months. The main objective of the study was to assess treatment efficacy in comparison with the 12 months pretreatment period. The number of exacerbation decreased in 8, did not change in 3 and increased in 3 patients. There was 9 severe exacerbation in the pretreatment year and only 1 in treatment period. By the end of therapy year disability decreased 0.68 according to Expanded Disability Status Scale outcome measure showing improvement in 1 of the major functional systems affected. Side effects, that were mild, appeared during the first three therapy months. The results suggest that interferon-beta-1a in dose of 11 mg given twice weekly seems effective in reducing disability in relapsing-remitting multiple sclerosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA