Pregled bibliografske jedinice broj: 806306
TPL2-NPM-p53 pathway monitors nucleolar stress
TPL2-NPM-p53 pathway monitors nucleolar stress // Oncoscience, 2 (2015), 11; 892-893 doi:10.18632/oncoscience.254 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 806306 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
TPL2-NPM-p53 pathway monitors nucleolar stress
Autori
Eliopoulos, Aristides G. ; Volarević, Siniša
Izvornik
Oncoscience (2331-4737) 2
(2015), 11;
892-893
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
TPL2; nucleolus; nucleophosmin; p53
Sažetak
Tumor Progression Locus 2 (TPL2) is widely recognized as a cytoplasmic mitogen-activated protein 3 kinase with a prominent role in the regulation of inflammatory and oncogenic signal transduction. TPL2 may also operate in the nucleus as a physical and functional partner of nucleophosmin (NPM/B23), a major nucleolar phosphoprotein with diverse cellular activities linked to malignancy. NPM is an endogenous inhibitor of HDM2:p53 interaction and knockdown of TPL2 has a role to reduce binding of NPM to HDM2, with concomitant defects in p53 accumulation following genotoxic or ribosomal stress.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-1081347-0370 - Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo (Volarević, Siniša, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Siniša Volarević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
