Naslov
Analysis of some phenothypic traits in a sample of multiple sclerosis patients

Autori
Ristić, Smiljana ; Sepčić, Juraj ; Kapović, Miljenko ; Brajenović-Milić, Bojana ; Materljan, Eris ; Rudež, Josip

Izvornik
Balkan Journal of Medical Genetics (1311-0160) 3 (2000), 3; 11-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multiple sclerosis; Genetics; Phenothypic traits

Sažetak
In the frame of complex researches of multiple sclerosis(MS) in Western Croatia, high risk zone for MS, the authors compared the genetic structure of MS patients(N=105) with that of healthy persons(N=334). A complex of 50 phenotypic traits was observed under the assumption that each trait is controlled by a corresponding gene. A statistically significant difference was found in 31 phenotypic traits between the group of MS patients and that of healthy controls, which indicates that the genetic structure in two groups could differ in 62% of allelogenes.Although an increased recessive homozygosity was noticed in the entire population, it was nevertheless by 23% higher in the sample of MS patients than in controls.Genes determining the phenothypic traits with evident differences between MS patients and controls could be the markers for polygenes participating in the process of creating either susceptibility or resistance to MS. Genetic loads arising as the consequence of increased recessive homozygosity in MS patient may disrupt the genetic-physiological homeostasis of the body and be the cause of reduced resistance towards environmental triggers of MS

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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