Naslov
Gender related differences in mouse blood cell responses to genotoxic properties of subchronic in vivo exposure to carbendazim

Autori
Mojsović-Ćujić, A., Benković, V., Landeka, I., Anđić, I., Đikić, D.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY 2012 ; 63(Suppl. 2) Abstracts of the 4th Croatian Congress of Toxicology (CROTOX 2012) / Davor Želježić - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2012, 58-58

Skup
4th Croatian Congress of Toxicology (CROTOX 2012) with international participation

Mjesto i datum
Primošten, Hrvatska, 02.10.2012. - 05.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aneugen ; immunotoxic effects ; leukocytes ; micronucleus assay ; red blood cells ; Swiss mice

Sažetak
The pesticide and preservative carbendazim is a chemical widely used in experiments as a known aneugen. It remains unclear whether it has clastogenic properties. In this study it was demonstrated that the subchronic repeated exposure (28 days) of mice to 20 mg kg-1 carbendazim (1/2 of NOEL dose), caused increased DNA breakage in leukocytes of peripheral blood, proving that the subchronic repeated exposure may cause clastogenic activity in sensible cells such as leukocytes. A decrease in RBC count, whose antioxidant defence mechanisms increased, was also noted. However, these effects were more pronounced only in males and not females, indicating that the males were more sensitive to the described clastogenic properties and hematotoxicity. On the contrary, the micronucleus assay showed that in terms of aneugenic properties both genders responded similarly. Parallel to this, there was an increase in granulocyte number (neutrophils, eosinophils, and basophils) in both sexes, indicating possible immunotoxic (allergenic) effects of prolonged carbendazim exposure.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA