Naslov
Changes in post-tetanic potentiation of A-fiber dorsl horn field potentials parallel the development and disappearence of neuropathic pain after sciatic nerve ligation in rats

Autori
Draganić, Pero ; Miletic, Gordana ; Miletic, Vjekoslav

Izvornik
Neuroscience Letters (0304-3940) 301 (2001); 127-130

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Synaptic plasticity; Nociception; Chronic pain; Primary afferents; Long-term potentiation

Sažetak
Significant plastic changes in spinal nociceptive processing appear to accompany peripheral nerve injury of inflamation. Using a well-established model of neuropathic pain, we have recently reported that loose ligation of the sciatic nerve was accompanied by a long-lasting post-tetanic potentiation of sciatic-evoked A-fiber superficial dorsal horn field potentials. In the present study we demonstrate that the typical disappearence of thermal hyperagesia as a behavioral sign of neuropathic pain several weeks after loose sciatic nerve ligation is accompanied by the loss of the long-lasting potentiation. These data suggest that a significant but reversible shift in the processing of sensory information in the spinal dorsal horn follows peripheral nerve injury, and lend further support to the notion that long-lasting synaptic plasticity may contribute to the development of neuropathic pain.

Izvorni jezik
Engleski

Znanstvena područja
Geologija

POVEZANOST RADA