Naslov
Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery

Autori
Škalamera, Đani ; Bohne, Cornelia ; Landgraf, Stephan ; Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CECP 2016 / Central European Conference on Photochemistry - Bad Hofgastein, Austria / - , 2016

Skup
CECP 2016 / Central European Conference on Photochemistry

Mjesto i datum
Bad Hofgastein, Austrija, 14.02.2016. - 18.02.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
quinone methides ; photodeamination ; cucurbit[n]urils ; supramolecular complexes ; cross-linking DNA

Sažetak
Quinone methides (QM) are commonly encountered reactive intermediates in chemistry and photochemistry of phenols, particularly interesting due to their biological activity.[1] Appropriately substituted bifunctional QMs cross-link DNA or peptides and proteins, which leads to disruption of cell maintenance and replication. Moreover, some QMs are reactive intermediates responsible for the action of antibiotics for anticancer therapy.[2] In a recent publication we have reported mechanistic details on the photochemical deamination of Mannich salts 1 and 2 that deliver long-lived QMs.[3] Preliminary antiproliferative investigation of 1 and 2 showed that compounds exhibit no enhancement of antiproliferative effect on irradiation of cancer cells. The objective of the current research is to show that 1 and 2 form inclusion complexes with cucurbit[n]urils (CB[n]s) which might facilitate their transport through cell membranes. Therefore, photochemical formation of QMs in a CB[n] complex and subsequent dissociation can have potential to be developed into a new drug delivery method.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA