Naslov
Explorations of mechanochemical Friedel-Crafts acylations

Autori
Đud, Mateja ; Štrukil, Vjekoslav ; Margetić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
PACIFICHEM 2015 International Chemical Congress of Pacific Basin Societies

Mjesto i datum
Honolulu (HI), Sjedinjene Američke Države, 15.12.2015. - 20.12.2015

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Friedel-Crafts acylation ; mechanochemistry ; mechanism

Sažetak
Friedel-Crafts acylation reactions were exploited in the preparation of ketone functionalized aromatics (Scheme 1). For this purpose, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed [1]. Reaction parameters such as FC catalyst, time, ratio of reagents, milling support, frequency of milling, size and number of milling balls, solvents for liquid assisted grinding were studied to establish the optimal reaction conditions [2]. To explore the scope of the reaction, different aromatic hydrocarbons were used in conjuction with anhydrides and acyl halides. It was shown that certain FC reactive aromatics could be effectively functionalized by FC acylations carried out in ball-milling conditions without the presence of solvent.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA