Naslov
Changes in nutrition type between generations influence on bone structural changes in female offspring

Autori
Marić, Anđela ; Perić Kačarević, Željka ; Vrselja, Zvonimir ; Radić, Radivoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Obesity Facts / Johannes Hebebrand - Ettlingen : Karger Publishers, 2015, 195-195

ISBN
978-3-318-05493-4

Skup
22nd European Congress on Obesity

Mjesto i datum
Prag, Češka Republika, 06.05.2015. - 09.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
obesity; bone microstructure; offspring

Sažetak
Introduction: It is believed that changes in feeding protocol between generations have influence on the balance of the whole organism. Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. The aim of the study was to determinate impact of maternal dietary fat excess and nutrition of female offspring on the bone structural changes. Methods: Ten female Sprague Dawley rats were randomly divided in two groups. One group was fed with high content of saturated fatty acid food(HFD) and the other one with standard laboratory chow (CD). Offspring from both groups were randomly divided in two subgroups after coupling and lactation period, subsequently there were four groups of offspring (n=6 each) with different feeding protocol: a) CD-CD – control diet mothers and offspring, b) CD-HFD – control diet mothers and high fat diet offspring, c) HFD-CD – high fat diet mothers and control diet offspring and d) HFD-HFD – high fat diet mothers and offspring. At the age of 18 weeks in female offspring bone microstructure was analyzed in fifth lumbar vertebra using digital photographic images. Results: The control diet female offspring of high fat fed mothers showed the highest values of trabecular thickness and trabecular number, while the CD-HFD offspring group had the highest values of trabecular separation and cortical thickness. Conclusion: Maternal nutritional status affects the future bone development of female offspring

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA