Naslov
Putative Hormone with Antiobesogenic and Insulin-Sensitizing Effect

Autori
Šoša, Ivan ; Grubešić, Aron

Izvornik
International journal of immunopathology and pharmacology (0394-6320) 29 (2016), 1; 147-148

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
BMP-9; Endothelium; NO

Sažetak
It was confirmed that bone morphogenetic protein – 9 (BMP-9), like insulin, improves glycaemia in diabetic mice and regulates glucose metabolism in hepatocytes, which is why it is proposed as a candidate for the hepatic insulin-sensitizing substance (HISS). Regarding the fact that BMP9 has the signalling pathway alike other BMPs and insulin too, it is to expect that BMP-9 has certain effects regarding the liver. In our 2011 hypothesis, we did aim towards BMP-9 as a possible “hepatic insulin-sensitizing substance” (HISS) and in this article, we provide evidences from the literature suggesting that this putative hormone might in fact be none other than BMP-9. .

Izvorni jezik
Engleski

POVEZANOST RADA