Pregled bibliografske jedinice broj: 787945
Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code
Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code // Proceedings of the 8th International Congress of Croatian Society of Mechanics / Kožar, Ivica ; Bićanić, Nenad ; Jelenić, Gordan ; Čanađija, Marko (ur.).
Rijeka: -, 2015. (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 787945 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code
Autori
Virag, Lana ; Vindiš, Vedran ; Sorić, Jurica ; Karšaj, Igor
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of the 8th International Congress of Croatian Society of Mechanics
/ Kožar, Ivica ; Bićanić, Nenad ; Jelenić, Gordan ; Čanađija, Marko - Rijeka, 2015
ISBN
978-953-7539-21-4
Skup
8th International Congress of Croatian Society of Mechanics
Mjesto i datum
Opatija, Hrvatska, 29.09.2015. - 02.10.2015
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
thrombus; aneurysm; G&R
Sažetak
Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta characterized by formation of intraluminal thrombus (ILT). These thrombi biologically and mechanically influence growth and remodeling (G&R) of AAAs, and therefore, they should not be treated as homogenous inert material. Yet, hitherto developed computational growth and remodeling models have neglected complex biochemomechanical influence of the thrombus on the evolution of the disease. Due to significant loss of functional elastin and smooth muscle, collagen remains the principal load-bearing constituent in the aneurysmal wall, and therefore its turnover and mechanical properties were believed to have a critical role in the natural history of the lesion. Yet, our comprehensive growth and remodeling model of thrombus-laden AAAs applied to cylindrical geometry, suggested collagen properties, albeit important, are not the only ones to determine clinical outcome of AAA enlargement. Additionally, the computational results showed that biochemical and biomechanical properties of ILT have a great influence on AAA growth pattern, and are a likely cause of discontinuous growth. Therefore, in order to confirm these hypotheses, there is a need to improve modeling of collagen fibers and to use more realistic geometries, i.e. implement model into finite element code.
Izvorni jezik
Engleski
Znanstvena područja
Strojarstvo
