Pregled bibliografske jedinice broj: 787385
Estimation of chromatographic lipophilicity of some D-homo androstene derivatives
Estimation of chromatographic lipophilicity of some D-homo androstene derivatives // Acta Periodica Technologica, 46 (2015), 249-258 doi:10.2298/APT1546249P (međunarodna recenzija, članak, znanstveni)
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Naslov
Estimation of chromatographic lipophilicity of some D-homo androstene derivatives
Autori
Perišić Janjić, Nada ; Penov Gaši, Katarina ; Djurendić, Evgenija ; Savić, Marina ; Kovačević, Strahinja ; Jokić, Stela ; Podunavac-Kuzmanović, Sanja
Izvornik
Acta Periodica Technologica (1450-7188) 46
(2015);
249-258
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
QSRR ; chemometrics ; RP HPTLC ; lipophilicity
Sažetak
Quantitative structure-retention relationship (QSRR) method was applied to study the chromatographic behaviour of D-homo-androstene derivatives 1-7. Retention constants (RM 0) of the analysed derivatives were determined by reversed-phase high-performance thin-layer chromatography (RP HPTLC) on C18 plates by using four mobile phase mixtures: methanol-water, acetone-water, acetonitrile-water, and dioxane-water. Correlation analysis based on multiple regression method was applied in order to model chromatographic retention by means of nine different lipophilicity descriptors (logP). The developed QSRR models were cross-validated and high-quality validation parameters were obtained by leave-one-out method. It was found that the derived QSRR models have a good predictive ability.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo, Biotehnologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
Uključenost u ostale bibliografske baze podataka::
- CAB Abstracts
