Naslov
Streptococcus pneumoniae resistance in children

Autori
Pavlov , Neven ; Kaliterna , Vanja ; Šitum , Marijan ; Tonkić , Marija ; Dragišić-Ivulić , Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Annual Congress Madrid, European Respiratory Society, Abstracts / European Respiratory Society - Madrid : European Respiratory Society, 1999, 452-453

Skup
ERS Annual Congress Madrid 1999

Mjesto i datum
Madrid, Španjolska, 09.10.1999. - 13.10.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Streprococcus pneumoniae; Rezistencija; Dijete
(Streprococcus pneumoniae; Resistance; Children)

Sažetak
We researched retrospectively frequency of airways infection in children hospitalised in Department of Pediatrics during 1997 caused by Streptococcus pneumoniae (SP) and its antibiotic susceptibility. Antibiotic susceptibility of SP was defined by disc diffusion technique, using 1 mcg oxacillin disc, with 25 mm cut of zone. Total number of hospitalised children was 2499 and 792 (32%) had respiratory tract infection (RTI). Nasal and pharyngeal swabs were analysed from 489 children (62% of children with RTI). Positive bacteriological culture was found in 186 children (38%). 223 pathogens were isolated (23% of all swabs): SP in 53 (24%), Staphylococcus aureus (SA): 80 (36%), Haemophylus influenzae in 36 (16%), Streptococcus pyogenes in 35 (16%) and others in 19 (8%) of all isolates. SP was isolated from 53 swabs of 46 children, 27 (51%) from pharyngeal swabs, 25 (47%) from nasal swabs and 1 (2%) from blood culture. 7 children (13%) had SP isolated from both swabs. Resistance of SP to benzylpenicillin was found in 73, 6%, to Azithromycin in 28, 1%, to Cotrimoxazole in 27%, to Erythromycin in 19, 4%, to Cefotaxime in 17% and to Clindamycin in 8%. SP showed moderate sensitivity to Ceftriaxone in 16, 3%, to Cotrimoxazole in 14%, to Erythromycin in 6, 4% and to Azithromycin in 3, 1%. SP was sensitive to benzylpenicillin in 26, 4%, to Vancomycin in 100%, to Clindamycin in 92%, to Ceftriaxone in 83, 7%, to Erythromycin in 74, 2%, to Azithromicin in 68, 8% and Cotrimoxazole in 59%. Conclusion: The presented results confirm that RTI are the most frequent disease among children (32% of all hospitalised children). SA is the most frequent isolated pathogen (35, 9%), then SP (23, 75%). Penicillin resistance of SP is high (73, 6%). It is necessary to define MIC for beta-laktams of clinical important isolates and to correct initial antibiotic therapy in RTI caused by SP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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