Pregled bibliografske jedinice broj: 786142
Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent
Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent // Analytical letters, 49 (2016), 5; 607-617 doi:0.1080/00032719.2014.996811 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 786142 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent
Autori
Kukoc-Modun, Lea ; Tsikas, Dimitrios ; Biocic, Maja ; Radić, Njegomir
Izvornik
Analytical letters (0003-2719) 49
(2016), 5;
607-617
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cu(II)-neocuproine reagent ; flow-injection analysis ; N-acetyl-L-cysteine ; spectrophotometric determination
Sažetak
A novel flow-injection analysis spectrophotometric procedure for the determination of N-acetyl-L-cysteine in pharmaceutical formulations is reported. The method is based on the reduction of Cu(II)- neocuproine to Cu(I)-neocuproine by the sulfhydryl group of N-acetyl-L-cysteine in aqueous solution at pH = 3. The absorbance of the yellow Cu(I)-neocuproine complex was measured at 458 nanometers. The primary chemical and instrumental variables were examined thoroughly. The method was validated in terms of linear dynamic range, limit of detection, limit of quantitation, selectivity, precision, and accuracy. Measurements confirmed its suitability for the reliable determination of N-acetyl-L-cysteine in pharmaceutical preparations at a sampling rate of 180 analyses per hour.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
011-0000000-3217 - Određivanje tiola primjenom potenciometrijskih senzora i spektroskopije (Radić, Njegomir, MZOS ) ( CroRIS)
Ustanove:
Kemijsko-tehnološki fakultet, Split
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
