Naslov
Pyoderma Gangrenosum Associated with Ulcerative Colitis

Autori
Ljubojević, Suzana ; Milavec-Puretić, Višnja ; Sredoja-Tišma, Vesna ; Radoš, Jaka ; Kalauz, Mirjana ; Hrstić, Irena

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 14 (2005), 1; 35-39

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
pyoderma gangrenosum ; ulcerative colitis ; therapy

Sažetak
We report the case of a 45-year old man with nonhealing ulcers located on his chest, lumbal, sacral, retroauricular areas and forehead. Both clinical and histopathological examinations suggested pyoderma gangrenosum (PG). For six months the diagnosis of ulcerative colitis was established. PG in our patient was presented as a rapidly enlarging, painful ulcer with purple, undermined edges and a necrotic, haemorrhagic base. Initially, he was treated with a high dosage of peroral glucocorticosteroid, sulfasalazine, and systemic antibiotics, together with daily wound care. Ulceration partially regressed. Total colonoscopy showed pancolitis. When the dose of glucocorticosteroids was tapered down to 35 mg, new ulcerations on his right thigh and abdomen were formed. He also developed E. coli sepsis and flare up of bowel disease. Azathioprine, together with two pulse doses of glucocorticosteroids and antibiotics, were administered. He was scheduled for a total colectomy. The management of PG continues to be a therapeutic challenge.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA